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Biotech Company Red Icon

Robust Pipeline with Large Market Potential

From our more advanced clinical program in Dupuytren’s disease to several preclinical programs ranging from an α7nAChR therapeutic for smoking cessation-induced ulcerative colitis to treatment of pain and early arthritis with SCAs, and several fibrosis and anti-TNF indications, our 3 families of drug candidates continue to meet milestones and show promising results.

We recently announced exciting results from our most advanced program in Dupuytren’s Contracture. The Phase 2b clinical trial was completed in 2021 and the published findings in The Lancet Rheumatology is available here.

  • Both the primary and secondary clinical trial endpoints from the Phase 2b clinical trial for patients with early-stage Dupuytren’s were statistically significant. Patients enrolled in the clinical trial exhibited a high compliance rate; almost all of them returned for all injections, and experienced no related serious adverse events.

In addition, a Phase 2 trial is projected to start in Q2/Q3 2023 in POCD.

Three families of novel drugs address significant market opportunities in inflammation, fibrosis and pain.

Anti-TNF (Clinical)

Dupuytren’s Contracture

Pursuing Conditional Marketing Authorization in UK

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  • Statistical significance was achieved in both the primary and secondary clinical trial endpoints.

  • Patients enrolled in the clinical trial exhibited a high rate of compliance; almost all returned for all injections.

  • No related serious adverse events.

POCD

Phase 2 Estimated start 2024

A custom progress meter

Frozen shoulder

Feasibility Study closed for enrollment Q1 2023

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  • New clinical site and country to be determined

NASH
Preclinical Started 2020

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SCAs

Chronic Pain
Preclinical ongoing; pharmacokinetic study expected to finish Q1 2024

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Weight Loss/Early Arthritis
Preclinical Ongoing; Phase 2 Will Begin Upon Successful Phase 1 in Chronic Pain

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Anti-TNF (Preclinical)

Smoking Cessation Induced Ulcerative Colitis
Preclinical Ongoing

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