α7nAChR

Led by Professor Lawrence Steinman and Dr. Jonathan Rothbard, stanford

Smoking cessation induced Ulcerative Colitis (UC)

After a decade of research on immune suppression in multiple sclerosis, Prof. Steinman and Dr. Rothbard identified a key receptor for the amyloid proteins associated with diseases like Alzheimer’s and Parkinson’s disease, called α7nAChR. The α7nAChR is expressed on the surface of both neuronal cells in the brain and on cells of the immune system. The research conducted by Dr. Rothbard and Prof. Steinman has shown that small molecules available as drugs taken by mouth can engage this receptor and potently reduce inflammatory diseases. They have further shown that this receptor is critical in reducing disease in animal models of multiple sclerosis and RA, as well as heart attack and stroke.

Competitive Advantages

Existing Therapies are Sub-Optimal

α7nAChR Advantages